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Friday 8 March 2013

Inhaled insulin for Alzheimers

I have recently read that inhaled insulin may be of help for patients with alzheimer’s dementia. Is this true?

Alzheimer’s dementia (AD) is a progressive disorder with no identifiable cause or effective treatment. All the drug treatments available today appear to have major side effects and the cognitive improvement is only marginal.

Now there is a study showing that intranasal insulin spray may be of benefit in patients with Alzheimer’s dementia. The researchers indicate that insulin is critical for normal brain function and alteration in its metabolism may be a contributing factor to the development of alzheimer's disease. The researchers mention that because some patients with AD have lower levels of insulin in the brain, perhaps delivering supplemental can help improve cognition.

So what does this mean for the consumer?

While these results may sound impressive they are fraught with errors. To date, there is no imaging technique that can reliably make a diagnosis of alzheimer's dementia. Moreover, there is no reliable way to measure insulin levels in the brain, asides from autopsy specimens. To claim that AD patients have low levels of insulin is false, because there is no scientific evidence for this statement.

In my opinion the study is not bona fide at all. First off all, if insulin was a cure for Alzheimer's dementia, then most type 1 diabetic patients would not never develop this disorder since they are treated with insulin for life. Clearly this is not the case. Secondly if insulin deficiency was a cause of alzheimer's dementia, only type 1 and type 2 diabetics would develop alzheimer's dementia- again this is not the case. Thirdly, administering insulin to a non diabetic patient is very risky. Hypoglycemia is a serious complication of insulin therapy and can be fatal if not recognized. If a doctor prescribes a non-diabetic patient insulin that leads to coma, you have a great malpractice case against the doctor.

To date, there is no evidence to show that diabetics (who lack insulin) have a higher prevalence of Alzheimer's dementia than non-diabetics.

Finally, any healthcare professional who prescribes insulin to non-diabetics better have good medical malpractice insurance.

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